{"id":143,"date":"2026-10-06T18:20:23","date_gmt":"2026-10-06T16:20:23","guid":{"rendered":"https:\/\/adnacademy.yohanndeprez.fr\/cas-cliniques\/obesite-severe\/"},"modified":"2026-10-06T18:46:45","modified_gmt":"2026-10-06T16:46:45","slug":"obesite-severe","status":"publish","type":"page","link":"https:\/\/adn-academy.com\/en\/cas-cliniques\/obesite-severe\/","title":{"rendered":"Clinical case: severe obesity"},"content":{"rendered":"<div class=\"wp-block-group adn-hero is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-hero-inner is-layout-flow wp-block-group-is-layout-flow\">\n<nav class=\"breadcrumb\" aria-label=\"Breadcrumb\"><a href=\"\/en\/\">Home<\/a><span aria-hidden=\"true\">\/<\/span><a href=\"\/en\/ressources\/\">Resources<\/a><span aria-hidden=\"true\">\/<\/span><a href=\"\/en\/cas-cliniques\/\">Clinical cases<\/a><span aria-hidden=\"true\">\/<\/span><span aria-current=\"page\">Severe obesity<\/span><\/nav>\n\n\n<p class=\"adn-hero-eyebrow wp-block-paragraph\">Clinical case \u00b7 Nutrition<\/p>\n\n\n<h1 class=\"wp-block-heading\">Severe obesity<\/h1>\n\n\n<p class=\"adn-hero-description wp-block-paragraph\">How can incorporating genetics and epigenetics improve care for people with severe obesity or excess weight?<\/p>\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"#etude\">Read the case<\/a><\/div>\n\n\n<div class=\"wp-block-button is-style-outline is-style-outline--1\"><a class=\"wp-block-button__link wp-element-button\" href=\"#video\">Watch the video<\/a><\/div>\n\n<\/div>\n\n<\/div>\n\n<\/div>\n\n\n<section id=\"etude\" class=\"wp-block-group adn-home-section adn-course-section adn-clinical-detail is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-home-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-clinical-layout is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-clinical-story is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-full adn-clinical-image adn-clinical-image--obesite-severe\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/adn-academy.com\/wp-content\/uploads\/2026\/10\/adn-obesite-severe.jpg\" alt=\"Illustration du cas clinique : Ob\u00e9sit\u00e9 s\u00e9v\u00e8re\" class=\"wp-image-139\" width=\"667\" height=\"1000\" srcset=\"https:\/\/adn-academy.com\/wp-content\/uploads\/2026\/10\/adn-obesite-severe.jpg 667w, https:\/\/adn-academy.com\/wp-content\/uploads\/2026\/10\/adn-obesite-severe-200x300.jpg 200w\" sizes=\"auto, (max-width: 667px) 100vw, 667px\" \/><\/figure>\n\n\n<p class=\"adn-clinical-byline wp-block-paragraph\">Case presented by Dr Dominique Cellier<\/p>\n\n\n<h2 id=\"contexte\" class=\"wp-block-heading\"><mark style=\"background-color:rgba(0, 0, 0, 0);color:#2E4057\" class=\"has-inline-color\">The clinical<\/mark> <mark style=\"background-color:rgba(0, 0, 0, 0);color:#279D5E\" class=\"has-inline-color\">context<\/mark><\/h2>\n\n\n<p class=\"wp-block-paragraph\">Marie-Christine, a 40-year-old night-shift nurse, has severe obesity with a BMI of 39 (160 cm, 101 kg). Since moving to night shifts, her weight gain has accelerated, making daily life increasingly difficult. She seeks advice after recently developing high blood pressure. This warning sign prompts her to look for a lasting solution.<\/p>\n\n\n<p class=\"wp-block-paragraph\">Brought up in a highly controlling family, Marie-Christine has been dieting since adolescence without ever managing to stabilise her weight. Despite repeated efforts, she has experienced a succession of setbacks that have deeply affected her self-esteem. She describes considerable emotional distress. She says she \"gives in\" when restrictions become too difficult and feels guilty and powerless, convinced that \"nothing works\".<\/p>\n\n\n<p class=\"wp-block-paragraph\">Although her healthcare professionals recommend more exercise, Marie-Christine feels anxious and discouraged. Her weight, unsuccessful diets and night-shift schedule create a vicious circle in which tiredness, hunger and frustration build up. Single and isolated in her attempts to lose weight, she arrives at the consultation exhausted and with low self-esteem, but still determined to understand why nothing has ever worked for her.<\/p>\n\n\n<h2 id=\"analyse\" class=\"wp-block-heading\"><mark style=\"background-color:rgba(0, 0, 0, 0);color:#2E4057\" class=\"has-inline-color\">The role of<\/mark> <mark style=\"background-color:rgba(0, 0, 0, 0);color:#279D5E\" class=\"has-inline-color\">the FTO gene<\/mark><\/h2>\n\n\n<p class=\"wp-block-paragraph\">After stopping the restrictive diets that had intensified her guilt and sense of failure, a comprehensive laboratory assessment is carried out to rule out any endocrine cause. Given her history of persistent hunger, difficulty feeling full and repeated failure of low-calorie diets, genetic testing is proposed to investigate, in particular, the FTO gene (fat mass and obesity associated).<\/p>\n\n\n<p class=\"wp-block-paragraph\">Three weeks later, the results confirm the presence of a polymorphism, explaining her constant hunger and inability to sustain calorie restriction. This finding brings her real relief and an objective explanation for her difficulties. Psychological support is then introduced to help her move away from family blame and regain confidence.<\/p>\n\n\n<p class=\"wp-block-paragraph\">The nutritional approach focuses on more frequent meals that are higher in protein and fibre, to stabilise hunger without frustration. She also begins appropriate, gradual physical activity that does not cause anxiety.<\/p>\n\n\n<p class=\"wp-block-paragraph\">Gradually, Marie-Christine regains energy, feels calmer and begins to lose weight steadily, reaching a loss of almost 9 kilos. Returning to day shifts consolidates her progress by restoring an eating pattern more in keeping with her natural rhythms. Her newly developed high blood pressure returns to normal, and she achieves a lasting balance.<\/p>\n\n\n<h2 id=\"formation\" class=\"wp-block-heading\"><mark style=\"background-color:rgba(0, 0, 0, 0);color:#2E4057\" class=\"has-inline-color\">Genetics and epigenetics<\/mark> <mark style=\"background-color:rgba(0, 0, 0, 0);color:#279D5E\" class=\"has-inline-color\">applied to nutrition<\/mark><\/h2>\n\n\n<p class=\"wp-block-paragraph\">Today, understanding genetics and epigenetics has become essential to developing truly personalised, more pragmatic and genuinely preventive medicine. Understanding how genetic and epigenetic variations influence individual responses enables us to fine-tune our recommendations and support each patient more appropriately and effectively.<\/p>\n\n\n<p class=\"wp-block-paragraph\">ADNAcademy\u2019s Genetics and Nutrition course supports you in this development. It provides the tools to integrate this knowledge into everyday practice, anticipate individual responses to nutritional advice and refine your approach for greater clinical relevance and impact.<\/p>\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"\/en\/formations\/genetique-nutrition\/\">Explore the course<\/a><\/div>\n\n\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-orange-background-color has-background wp-element-button\" href=\"#programme\">Get the course programme<\/a><\/div>\n\n<\/div>\n\n<\/div>\n\n\n<aside class=\"wp-block-group adn-course-panel adn-clinical-aside is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"adn-section-label wp-block-paragraph\">The practitioner\u2019s perspective<\/p>\n\n\n<figure class=\"wp-block-image size-full adn-clinical-portrait\"><img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"200\" src=\"https:\/\/adn-academy.com\/wp-content\/uploads\/2026\/09\/dominique-cellier.jpg\" alt=\"Dominique Cellier\" class=\"wp-image-72\" srcset=\"https:\/\/adn-academy.com\/wp-content\/uploads\/2026\/09\/dominique-cellier.jpg 200w, https:\/\/adn-academy.com\/wp-content\/uploads\/2026\/09\/dominique-cellier-150x150.jpg 150w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/figure>\n\n\n<h3 class=\"wp-block-heading\">Dominique Cellier<\/h3>\n\n\n<p class=\"adn-clinical-role wp-block-paragraph\">Physician specialising in nutrition \u00b7 Scientific Director<\/p>\n\n\n<p class=\"wp-block-paragraph\">Passionate about patient support and therapeutic education, Dominique Cellier draws on 20 years of research into obesity and excess weight, as well as behavioural and genetic mechanisms. He is the author of the Genetics &amp; Nutrition course.<\/p>\n\n\n<nav class=\"adn-clinical-nav\" aria-label=\"In this clinical case\"><a href=\"#contexte\">The clinical context <span aria-hidden=\"true\">\u2192<\/span><\/a><a href=\"#analyse\">Assessment and management <span aria-hidden=\"true\">\u2192<\/span><\/a><a href=\"#video\">The practitioner\u2019s video <span aria-hidden=\"true\">\u2192<\/span><\/a><\/nav>\n\n<\/aside>\n\n<\/div>\n\n<\/div>\n\n<\/section>\n\n\n<section id=\"video\" class=\"wp-block-group adn-home-section adn-course-section adn-section-tinted adn-clinical-video-section is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-home-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-section-heading is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"adn-section-label wp-block-paragraph\">The practitioner explains<\/p>\n\n\n<h2 class=\"wp-block-heading\"><mark style=\"background-color:rgba(0, 0, 0, 0);color:#2E4057\" class=\"has-inline-color\">The clinical case<\/mark> <mark style=\"background-color:rgba(0, 0, 0, 0);color:#279D5E\" class=\"has-inline-color\">on video<\/mark><\/h2>\n\n\n<p class=\"adn-section-intro wp-block-paragraph\">An explanation by Dr Dominique Cellier, a physician specialising in nutrition and author of the Genetics &amp; Nutrition course.<\/p>\n\n<\/div>\n\n\n<figure class=\"wp-block-video adn-clinical-video adn-video-cover\"><video height=\"1080\" style=\"aspect-ratio: 1920 \/ 1080;\" width=\"1920\" controls playsinline preload=\"none\" poster=\"https:\/\/adn-academy.com\/wp-content\/uploads\/2026\/10\/adn-obesite-severe.jpg\" src=\"https:\/\/adn-academy.com\/wp-content\/uploads\/2026\/10\/adn-cas-clinique-obesite.mp4\"><\/video><\/figure>\n\n<\/div>\n\n<\/section>\n\n\n<section id=\"programme\" class=\"wp-block-group adn-home-section adn-course-section is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-home-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-course-enquiry is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-course-copy is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-section-heading is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"adn-section-label wp-block-paragraph\">Explore further<\/p>\n\n\n<h2 class=\"wp-block-heading\"><mark style=\"background-color:rgba(0, 0, 0, 0);color:#2E4057\" class=\"has-inline-color\">Get<\/mark> <mark style=\"background-color:rgba(0, 0, 0, 0);color:#279D5E\" class=\"has-inline-color\">the detailed programme<\/mark><\/h2>\n\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">Explore these topics further with the <strong>Genetics &amp; Nutrition<\/strong>course. Discover its content and speak to the ADNAcademy team.<\/p>\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-outline is-style-outline--2\"><a class=\"wp-block-button__link wp-element-button\" href=\"\/en\/formations\/genetique-nutrition\/\">Explore the course<\/a><\/div>\n\n<\/div>\n\n<\/div>\n\n\n<div class=\"wp-block-group adn-course-form is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"adn-form-consent\"><p>This form is provided by HubSpot. Allow it to load to receive the programme or request enrolment.<\/p><button type=\"button\" class=\"adn-button\" data-cookie-settings>Show the form<\/button><\/div><div class=\"adn-hubspot-mount\" data-hubspot-form=\"b209f8a7-aac5-4a30-acd7-d64a99648aa6\"><\/div><noscript><p>Enable JavaScript to view the form, or contact us at <a href=\"mailto:contact@adn-academy.com\">contact@adn-academy.com<\/a>.<\/p><\/noscript>\n\n<\/div>\n\n<\/div>\n\n<\/div>\n\n<\/section>\n\n\n<section class=\"wp-block-group adn-home-section adn-course-section adn-section-tinted adn-clinical-back is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-home-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"\/en\/cas-cliniques\/\">All clinical cases<\/a><\/div>\n\n\n<div class=\"wp-block-button is-style-outline is-style-outline--3\"><a class=\"wp-block-button__link wp-element-button\" href=\"\/en\/ressources\/\">Explore our resources<\/a><\/div>\n\n<\/div>\n\n<\/div>\n\n<\/section>","protected":false},"excerpt":{"rendered":"<p>Le parcours d\u2019une patiente de 40 ans, infirmi\u00e8re de nuit, confront\u00e9e \u00e0 une ob\u00e9sit\u00e9 s\u00e9v\u00e8re et \u00e0 des r\u00e9gimes r\u00e9p\u00e9t\u00e9s. Un cas pr\u00e9sent\u00e9 par le Dr Dominique Cellier.<\/p>","protected":false},"author":1,"featured_media":139,"parent":21,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-143","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/pages\/143","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/comments?post=143"}],"version-history":[{"count":2,"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/pages\/143\/revisions"}],"predecessor-version":[{"id":202,"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/pages\/143\/revisions\/202"}],"up":[{"embeddable":true,"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/pages\/21"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/media\/139"}],"wp:attachment":[{"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/media?parent=143"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}