{"id":144,"date":"2026-10-06T18:20:25","date_gmt":"2026-10-06T16:20:25","guid":{"rendered":"https:\/\/adnacademy.yohanndeprez.fr\/cas-cliniques\/parodontite-severe\/"},"modified":"2026-11-10T10:38:01","modified_gmt":"2026-11-10T09:38:01","slug":"parodontite-severe","status":"publish","type":"page","link":"https:\/\/adn-academy.com\/en\/cas-cliniques\/parodontite-severe\/","title":{"rendered":"Clinical case: severe periodontitis"},"content":{"rendered":"<div class=\"wp-block-group adn-hero is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-hero-inner is-layout-flow wp-block-group-is-layout-flow\">\n<nav class=\"breadcrumb\" aria-label=\"Breadcrumb\"><a href=\"\/en\/\">Home<\/a><span aria-hidden=\"true\">\/<\/span><a href=\"\/en\/ressources\/\">Resources<\/a><span aria-hidden=\"true\">\/<\/span><a href=\"\/en\/cas-cliniques\/\">Clinical cases<\/a><span aria-hidden=\"true\">\/<\/span><span aria-current=\"page\">Severe periodontitis<\/span><\/nav>\n\n\n<p class=\"adn-hero-eyebrow wp-block-paragraph\">Clinical case \u00b7 Dentistry<\/p>\n\n\n<h1 class=\"wp-block-heading\">Severe periodontitis<\/h1>\n\n\n<p class=\"adn-hero-description wp-block-paragraph\">How can incorporating genetics and epigenetics improve the management of persistent severe periodontitis?<\/p>\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"#etude\">Read the case<\/a><\/div>\n\n\n<div class=\"wp-block-button is-style-outline is-style-outline--1\"><a class=\"wp-block-button__link wp-element-button\" href=\"#video\">Watch the video<\/a><\/div>\n\n<\/div>\n\n<\/div>\n\n<\/div>\n\n\n<section id=\"etude\" class=\"wp-block-group adn-home-section adn-course-section adn-clinical-detail is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-home-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-clinical-layout is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-clinical-story is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-full adn-clinical-image adn-clinical-image--parodontite-severe\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/adn-academy.com\/wp-content\/uploads\/2026\/10\/adn-parodontite-severe.png\" alt=\"Illustration du cas clinique : Parodontite s\u00e9v\u00e8re\" class=\"wp-image-140\" width=\"1500\" height=\"1000\" srcset=\"https:\/\/adn-academy.com\/wp-content\/uploads\/2026\/10\/adn-parodontite-severe.png 1500w, https:\/\/adn-academy.com\/wp-content\/uploads\/2026\/10\/adn-parodontite-severe-300x200.png 300w, https:\/\/adn-academy.com\/wp-content\/uploads\/2026\/10\/adn-parodontite-severe-1024x683.png 1024w, https:\/\/adn-academy.com\/wp-content\/uploads\/2026\/10\/adn-parodontite-severe-768x512.png 768w\" sizes=\"auto, (max-width: 1500px) 100vw, 1500px\" \/><\/figure>\n\n\n<p class=\"adn-clinical-byline wp-block-paragraph\">Case presented by Dr Clotilde Neyra<\/p>\n\n\n<h2 id=\"contexte\" class=\"wp-block-heading\"><mark style=\"background-color:rgba(0, 0, 0, 0);color:#2E4057\" class=\"has-inline-color\">The clinical<\/mark> <mark style=\"background-color:rgba(0, 0, 0, 0);color:#279D5E\" class=\"has-inline-color\">context<\/mark><\/h2>\n\n\n<p class=\"wp-block-paragraph\">In my clinical dental practice, I treated a young patient, Yasmina, aged 7. She presented with severe periodontitis with a very early onset and no obvious aetiological factor.<\/p>\n\n\n<p class=\"wp-block-paragraph\">Despite dental care in line with recommendations and rigorous oral hygiene advice, the clinical course remained unfavourable, with persistent inflammation and rapid deterioration of the supporting tissues.<\/p>\n\n\n<p class=\"wp-block-paragraph\">Faced with this atypical presentation in paediatric dentistry and the lack of response to conventional treatment, I chose to investigate the diagnosis further by requesting a genetic test to explore a possible underlying systemic or genetic cause.<\/p>\n\n\n<h2 id=\"analyse\" class=\"wp-block-heading\"><mark style=\"background-color:rgba(0, 0, 0, 0);color:#2E4057\" class=\"has-inline-color\">Identifying<\/mark> <mark style=\"background-color:rgba(0, 0, 0, 0);color:#279D5E\" class=\"has-inline-color\">a rare disease<\/mark><\/h2>\n\n\n<p class=\"wp-block-paragraph\">Genetic testing identified a moderate form of Papillon-Lef\u00e8vre syndrome in the patient, a rare hereditary disease known for its severe, early periodontal manifestations. This aetiological diagnosis profoundly changed the treatment strategy.<\/p>\n\n\n<p class=\"wp-block-paragraph\">Care could be tailored specifically, including targeted antibiotic therapy, close periodontal follow-up and enhanced prevention. Above all, the discovery enabled early screening of her siblings, paving the way for proactive monitoring and effective prevention of dental complications.<\/p>\n\n\n<p class=\"wp-block-paragraph\">Without this genetic investigation, these children would very likely have experienced early tooth loss, with major consequences for chewing function, appearance and quality of life. This clinical case provides a concrete illustration of the growing importance of genetics in diagnosis and care in modern dentistry.<\/p>\n\n\n<h2 id=\"formation\" class=\"wp-block-heading\"><mark style=\"background-color:rgba(0, 0, 0, 0);color:#2E4057\" class=\"has-inline-color\">Genetics and epigenetics<\/mark> <mark style=\"background-color:rgba(0, 0, 0, 0);color:#279D5E\" class=\"has-inline-color\">applied to dentistry<\/mark><\/h2>\n\n\n<p class=\"wp-block-paragraph\">This clinical experience strongly reinforced a fundamental conviction: training in genetics is now essential in dentistry to offer patients more precise, truly personalised and firmly preventive care.<\/p>\n\n\n<p class=\"wp-block-paragraph\">Beyond improving diagnosis and treatment protocols, genetics helps put patients back at the centre of care, supporting dentistry that is more humane, more predictive and more respectful of each person\u2019s biological individuality.<\/p>\n\n\n<p class=\"wp-block-paragraph\">C\u2019est dans cette dynamique qu\u2019ADN Academy a d\u00e9velopp\u00e9 une formation d\u00e9di\u00e9e \u00e0 la g\u00e9n\u00e9tique appliqu\u00e9e \u00e0 la dentisterie. Con\u00e7ue pour accompagner les chirurgiens-dentistes dans l\u2019int\u00e9gration concr\u00e8te de cet outil innovant au c\u0153ur de leur pratique professionnelle.<\/p>\n\n\n<p class=\"wp-block-paragraph\">The aim is to understand better, anticipate better and provide better care, drawing on the scientific advances that are transforming modern dentistry today.<\/p>\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"\/en\/formations\/genetique-dentisterie\/\">Explore the course<\/a><\/div>\n\n\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-orange-background-color has-background wp-element-button\" href=\"#programme\">Get the course programme<\/a><\/div>\n\n<\/div>\n\n<\/div>\n\n\n<aside class=\"wp-block-group adn-course-panel adn-clinical-aside is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"adn-section-label wp-block-paragraph\">The practitioner\u2019s perspective<\/p>\n\n\n<figure class=\"wp-block-image size-full adn-clinical-portrait\"><img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"200\" src=\"https:\/\/adn-academy.com\/wp-content\/uploads\/2026\/09\/clotilde-neyra.jpeg\" alt=\"Clotilde Neyra\" class=\"wp-image-73\" srcset=\"https:\/\/adn-academy.com\/wp-content\/uploads\/2026\/09\/clotilde-neyra.jpeg 200w, https:\/\/adn-academy.com\/wp-content\/uploads\/2026\/09\/clotilde-neyra-150x150.jpeg 150w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/figure>\n\n\n<h3 class=\"wp-block-heading\">Clotilde Neyra<\/h3>\n\n\n<p class=\"adn-clinical-role wp-block-paragraph\">Dentist \u00b7 Managing Director<\/p>\n\n\n<p class=\"wp-block-paragraph\">A general dental practitioner with an inter-university diploma in Precision Diagnostics and Personalised Medicine, Clotilde Neyra is the author of the Genetics &amp; Dentistry course.<\/p>\n\n\n<nav class=\"adn-clinical-nav\" aria-label=\"In this clinical case\"><a href=\"#contexte\">The clinical context <span aria-hidden=\"true\">\u2192<\/span><\/a><a href=\"#analyse\">Assessment and management <span aria-hidden=\"true\">\u2192<\/span><\/a><a href=\"#video\">The practitioner\u2019s video <span aria-hidden=\"true\">\u2192<\/span><\/a><\/nav>\n\n<\/aside>\n\n<\/div>\n\n<\/div>\n\n<\/section>\n\n\n<section id=\"video\" class=\"wp-block-group adn-home-section adn-course-section adn-section-tinted adn-clinical-video-section is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-home-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-section-heading is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"adn-section-label wp-block-paragraph\">The practitioner explains<\/p>\n\n\n<h2 class=\"wp-block-heading\"><mark style=\"background-color:rgba(0, 0, 0, 0);color:#2E4057\" class=\"has-inline-color\">Genetics &amp; dentistry<\/mark> <mark style=\"background-color:rgba(0, 0, 0, 0);color:#279D5E\" class=\"has-inline-color\">on video<\/mark><\/h2>\n\n\n<p class=\"adn-section-intro wp-block-paragraph\">An explanation by Dr Clotilde Neyra, dentist, Managing Director of ADNAcademy and author of the Genetics &amp; Dentistry course.<\/p>\n\n<\/div>\n\n\n<figure class=\"wp-block-video adn-clinical-video\"><video height=\"1080\" style=\"aspect-ratio: 1920 \/ 1080;\" width=\"1920\" controls playsinline preload=\"none\" poster=\"https:\/\/adn-academy.com\/wp-content\/uploads\/2026\/10\/adn-parodontite-severe.png\" src=\"https:\/\/adn-academy.com\/wp-content\/uploads\/2026\/10\/adn-cas-clinique-dentisterie.mp4\"><\/video><\/figure>\n\n\n<div class=\"wp-block-group adn-clinical-video-copy is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\">ALPL mutation (alkaline phosphatase)<\/h3>\n\n\n<p class=\"wp-block-paragraph\">A young child presents with premature tooth loss without obvious signs of periodontal inflammation.<\/p>\n\n\n<p class=\"wp-block-paragraph\">Genotyping could reveal a mutation in the ALPL gene and therefore a deficiency in the enzyme alkaline phosphatase. Appropriate treatment could then be offered.<\/p>\n\n<\/div>\n\n<\/div>\n\n<\/section>\n\n\n<section id=\"programme\" class=\"wp-block-group adn-home-section adn-course-section is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-home-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-course-enquiry is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-course-copy is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-section-heading is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"adn-section-label wp-block-paragraph\">Explore further<\/p>\n\n\n<h2 class=\"wp-block-heading\"><mark style=\"background-color:rgba(0, 0, 0, 0);color:#2E4057\" class=\"has-inline-color\">Get<\/mark> <mark style=\"background-color:rgba(0, 0, 0, 0);color:#279D5E\" class=\"has-inline-color\">the detailed programme<\/mark><\/h2>\n\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">Explore these topics further with the <strong>Genetics &amp; Dentistry<\/strong>course. Discover its content and speak to the ADNAcademy team.<\/p>\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-outline is-style-outline--2\"><a class=\"wp-block-button__link wp-element-button\" href=\"\/en\/formations\/genetique-dentisterie\/\">Explore the course<\/a><\/div>\n\n<\/div>\n\n<\/div>\n\n\n<div class=\"wp-block-group adn-course-form is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"adn-form-consent\"><p>This form is provided by HubSpot. Allow it to load to receive the programme or request enrolment.<\/p><button type=\"button\" class=\"adn-button\" data-cookie-settings>Show the form<\/button><\/div><div class=\"adn-hubspot-mount\" data-hubspot-form=\"bf217b99-e65a-4002-8719-c1bf9428132f\"><\/div><noscript><p>Enable JavaScript to view the form, or contact us at <a href=\"mailto:contact@adn-academy.com\">contact@adn-academy.com<\/a>.<\/p><\/noscript>\n\n<\/div>\n\n<\/div>\n\n<\/div>\n\n<\/section>\n\n\n<section class=\"wp-block-group adn-home-section adn-course-section adn-section-tinted adn-clinical-back is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-home-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"\/en\/cas-cliniques\/\">All clinical cases<\/a><\/div>\n\n\n<div class=\"wp-block-button is-style-outline is-style-outline--3\"><a class=\"wp-block-button__link wp-element-button\" href=\"\/en\/ressources\/\">Explore our resources<\/a><\/div>\n\n<\/div>\n\n<\/div>\n\n<\/section>","protected":false},"excerpt":{"rendered":"<p>Une parodontite s\u00e9v\u00e8re chez une enfant de 7 ans, conduisant \u00e0 l\u2019identification d\u2019un syndrome de Papillon-Lef\u00e8vre. Un cas pr\u00e9sent\u00e9 par le Dr Clotilde Neyra.<\/p>","protected":false},"author":1,"featured_media":140,"parent":21,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-144","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/pages\/144","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/comments?post=144"}],"version-history":[{"count":3,"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/pages\/144\/revisions"}],"predecessor-version":[{"id":321,"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/pages\/144\/revisions\/321"}],"up":[{"embeddable":true,"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/pages\/21"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/media\/140"}],"wp:attachment":[{"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/media?parent=144"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}