{"id":288,"date":"2026-11-02T13:09:55","date_gmt":"2026-11-02T12:09:55","guid":{"rendered":"https:\/\/adnacademy.yohanndeprez.fr\/cas-cliniques\/syndrome-intestin-irritable\/"},"modified":"2026-11-10T10:38:01","modified_gmt":"2026-11-10T09:38:01","slug":"syndrome-intestin-irritable","status":"publish","type":"page","link":"https:\/\/adn-academy.com\/en\/cas-cliniques\/syndrome-intestin-irritable\/","title":{"rendered":"Syndrome de l\u2019intestin irritable"},"content":{"rendered":"<div class=\"wp-block-group adn-hero is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-hero-inner is-layout-flow wp-block-group-is-layout-flow\">\n<nav class=\"breadcrumb\" aria-label=\"Breadcrumb\"><a href=\"\/en\/\">Home<\/a><span aria-hidden=\"true\">\/<\/span><a href=\"\/en\/ressources\/\">Resources<\/a><span aria-hidden=\"true\">\/<\/span><a href=\"\/en\/cas-cliniques\/\">Clinical cases<\/a><span aria-hidden=\"true\">\/<\/span><span aria-current=\"page\">Syndrome de l\u2019intestin irritable<\/span><\/nav>\n\n\n<p class=\"adn-hero-eyebrow wp-block-paragraph\">Clinical case \u00b7 Nutrition<\/p>\n\n\n<h1 class=\"wp-block-heading\">Syndrome de l\u2019intestin irritable<\/h1>\n\n\n<p class=\"adn-hero-description wp-block-paragraph\">Face \u00e0 des troubles digestifs chroniques sans anomalie d\u00e9cel\u00e9e, comment la compr\u00e9hension des pr\u00e9dispositions g\u00e9n\u00e9tiques et de l&#x27;interaction entre g\u00e8nes et environnement peut-elle enrichir l&#x27;accompagnement du patient ?<\/p>\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"#etude\">Read the case<\/a><\/div>\n\n\n<\/div>\n\n<\/div>\n\n<\/div>\n\n\n<section id=\"etude\" class=\"wp-block-group adn-home-section adn-course-section adn-clinical-detail is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-home-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-clinical-layout is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-clinical-story is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-full adn-clinical-image adn-clinical-image--syndrome-intestin-irritable\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/adn-academy.com\/wp-content\/uploads\/2026\/11\/adn-cas-syndrome-intestin-irritable.jpg\" alt=\"Illustration du cas clinique : Syndrome de l\u2019intestin irritable\" class=\"wp-image-287\" width=\"1366\" height=\"768\" srcset=\"https:\/\/adn-academy.com\/wp-content\/uploads\/2026\/11\/adn-cas-syndrome-intestin-irritable.jpg 1366w, https:\/\/adn-academy.com\/wp-content\/uploads\/2026\/11\/adn-cas-syndrome-intestin-irritable-300x169.jpg 300w, https:\/\/adn-academy.com\/wp-content\/uploads\/2026\/11\/adn-cas-syndrome-intestin-irritable-1024x576.jpg 1024w, https:\/\/adn-academy.com\/wp-content\/uploads\/2026\/11\/adn-cas-syndrome-intestin-irritable-768x432.jpg 768w, https:\/\/adn-academy.com\/wp-content\/uploads\/2026\/11\/adn-cas-syndrome-intestin-irritable-18x10.jpg 18w\" sizes=\"auto, (max-width: 1366px) 100vw, 1366px\" \/><\/figure>\n\n\n<p class=\"adn-clinical-byline wp-block-paragraph\">Case presented by Dr Dominique Cellier<\/p>\n\n<h2 id=\"contexte\" class=\"wp-block-heading\">Contexte clinique<\/h2>\n<p class=\"wp-block-paragraph\">Ir\u00e8ne, enseignante retrait\u00e9e, pr\u00e9sente depuis l&#x27;enfance des douleurs abdominales r\u00e9currentes, des ballonnements et un m\u00e9t\u00e9orisme important apr\u00e8s les repas. Malgr\u00e9 de nombreuses explorations m\u00e9dicales (TOGD, coloscopie, analyses biologiques et recherches parasitologiques), aucune cause organique n&#x27;a \u00e9t\u00e9 identifi\u00e9e. Ses sympt\u00f4mes s&#x27;intensifient lors de p\u00e9riodes de stress, d&#x27;angoisse ou de contrari\u00e9t\u00e9s. Passionn\u00e9e de cuisine, elle a progressivement multipli\u00e9 les exclusions alimentaires et limite sa vie sociale par crainte de l&#x27;inconfort digestif. Aucun traitement ne lui a apport\u00e9 de soulagement durable.<\/p>\n<h2 id=\"analyse\" class=\"wp-block-heading\">Le g\u00e8ne en cause : une pr\u00e9disposition multifactorielle<\/h2>\n<p class=\"wp-block-paragraph\">L&#x27;histoire clinique d&#x27;Ir\u00e8ne oriente vers un syndrome de l&#x27;intestin irritable (SII), caract\u00e9ris\u00e9 par l&#x27;absence d&#x27;anomalie identifi\u00e9e malgr\u00e9 des sympt\u00f4mes digestifs persistants. Les travaux scientifiques sugg\u00e8rent une susceptibilit\u00e9 g\u00e9n\u00e9tique multifactorielle impliquant les interactions entre le syst\u00e8me nerveux, le microbiote intestinal et l&#x27;environnement. Cependant, aucun g\u00e8ne unique ni aucun test g\u00e9n\u00e9tique valid\u00e9 ne permettent aujourd&#x27;hui de diagnostiquer ou de guider le traitement du SII. Les douleurs peuvent notamment \u00eatre li\u00e9es \u00e0 une hypersensibilit\u00e9 visc\u00e9rale et \u00e0 une perturbation de l&#x27;axe intestin-cerveau.<\/p>\n<h2 id=\"genetique\" class=\"wp-block-heading\">L&#x27;int\u00e9r\u00eat de la g\u00e9n\u00e9tique et de l&#x27;\u00e9pig\u00e9n\u00e9tique<\/h2>\n<p class=\"wp-block-paragraph\">La g\u00e9n\u00e9tique permet ici d&#x27;expliquer une pr\u00e9disposition, sans constituer un outil diagnostique du SII. Elle aide \u00e9galement \u00e0 distinguer d&#x27;autres pathologies digestives, comme la maladie c\u0153liaque, gr\u00e2ce \u00e0 l&#x27;\u00e9tude des haplotypes HLA-DQ2 et HLA-DQ8. Leur absence rend la maladie c\u0153liaque tr\u00e8s improbable, tandis que leur pr\u00e9sence seule ne suffit pas \u00e0 confirmer le diagnostic. L&#x27;\u00e9pig\u00e9n\u00e9tique souligne quant \u00e0 elle l&#x27;influence de facteurs tels que le stress, l&#x27;alimentation ou le mode de vie sur l&#x27;expression des pr\u00e9dispositions individuelles et sur l&#x27;intensit\u00e9 des sympt\u00f4mes.<\/p>\n<h2 id=\"accompagnement\" class=\"wp-block-heading\">Une prise en charge personnalis\u00e9e<\/h2>\n<p class=\"wp-block-paragraph\">L&#x27;objectif est de r\u00e9duire les sympt\u00f4mes sans renforcer les restrictions alimentaires. Un suivi associant journal alimentaire, analyse du transit et prise en compte du contexte \u00e9motionnel permet d&#x27;identifier les facteurs d\u00e9clenchants. Selon les besoins, une r\u00e9duction temporaire des FODMAP peut \u00eatre envisag\u00e9e puis suivie d&#x27;une r\u00e9introduction progressive. L&#x27;accompagnement int\u00e8gre \u00e9galement activit\u00e9 physique, gestion du stress et travail sur l&#x27;axe intestin-cerveau. Le but est de retrouver une alimentation vari\u00e9e, le plaisir de cuisiner et une vie sociale moins impact\u00e9e par l&#x27;anticipation des crises.<\/p>\n<\/div>\n\n<aside class=\"wp-block-group adn-course-panel adn-clinical-aside is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"adn-section-label wp-block-paragraph\">The practitioner\u2019s perspective<\/p>\n\n\n<figure class=\"wp-block-image size-full adn-clinical-portrait\"><img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"200\" src=\"https:\/\/adn-academy.com\/wp-content\/uploads\/2026\/09\/dominique-cellier.jpg\" alt=\"Dominique Cellier\" class=\"wp-image-72\" srcset=\"https:\/\/adn-academy.com\/wp-content\/uploads\/2026\/09\/dominique-cellier.jpg 200w, https:\/\/adn-academy.com\/wp-content\/uploads\/2026\/09\/dominique-cellier-150x150.jpg 150w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/figure>\n\n\n<h3 class=\"wp-block-heading\">Dominique Cellier<\/h3>\n\n\n<p class=\"adn-clinical-role wp-block-paragraph\">Physician specialising in nutrition \u00b7 Scientific Director<\/p>\n\n\n<p class=\"wp-block-paragraph\">Passionate about patient support and therapeutic education, Dominique Cellier draws on 20 years of research into obesity and excess weight, as well as behavioural and genetic mechanisms. He is the author of the Genetics &amp; Nutrition course.<\/p>\n\n\n<nav class=\"adn-clinical-nav\" aria-label=\"In this clinical case\"><a href=\"#contexte\">Contexte clinique <span aria-hidden=\"true\">\u2192<\/span><\/a><a href=\"#analyse\">Le g\u00e8ne en cause : une pr\u00e9disposition multifactorielle <span aria-hidden=\"true\">\u2192<\/span><\/a><a href=\"#genetique\">L&#x27;int\u00e9r\u00eat de la g\u00e9n\u00e9tique et de l&#x27;\u00e9pig\u00e9n\u00e9tique <span aria-hidden=\"true\">\u2192<\/span><\/a><a href=\"#accompagnement\">Une prise en charge personnalis\u00e9e <span aria-hidden=\"true\">\u2192<\/span><\/a><\/nav>\n\n<\/aside>\n\n<\/div>\n\n<\/div>\n\n<\/section>\n\n\n<section id=\"programme\" class=\"wp-block-group adn-home-section adn-course-section is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-home-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-course-enquiry is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-course-copy is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-section-heading is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"adn-section-label wp-block-paragraph\">Explore further<\/p>\n\n\n<h2 class=\"wp-block-heading\"><mark style=\"background-color:rgba(0, 0, 0, 0);color:#2E4057\" class=\"has-inline-color\">Get<\/mark> <mark style=\"background-color:rgba(0, 0, 0, 0);color:#279D5E\" class=\"has-inline-color\">the detailed programme<\/mark><\/h2>\n\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">Explore these topics further with the <strong>Genetics &amp; Nutrition<\/strong>course. Discover its content and speak to the ADNAcademy team.<\/p>\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-outline is-style-outline--1\"><a class=\"wp-block-button__link wp-element-button\" href=\"\/en\/formations\/genetique-nutrition\/\">Explore the course<\/a><\/div>\n\n<\/div>\n\n<\/div>\n\n\n<div class=\"wp-block-group adn-course-form is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"adn-form-consent\"><p>This form is provided by HubSpot. Allow it to load to receive the programme or request enrolment.<\/p><button type=\"button\" class=\"adn-button\" data-cookie-settings>Show the form<\/button><\/div><div class=\"adn-hubspot-mount\" data-hubspot-form=\"b209f8a7-aac5-4a30-acd7-d64a99648aa6\"><\/div><noscript><p>Enable JavaScript to view the form, or contact us at <a href=\"mailto:contact@adn-academy.com\">contact@adn-academy.com<\/a>.<\/p><\/noscript>\n\n<\/div>\n\n<\/div>\n\n<\/div>\n\n<\/section>\n\n\n<section class=\"wp-block-group adn-home-section adn-course-section adn-section-tinted adn-clinical-back is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-home-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"\/en\/cas-cliniques\/\">All clinical cases<\/a><\/div>\n\n\n<div class=\"wp-block-button is-style-outline is-style-outline--2\"><a class=\"wp-block-button__link wp-element-button\" href=\"\/en\/ressources\/\">Explore our resources<\/a><\/div>\n\n<\/div>\n\n<\/div>\n\n<\/section>","protected":false},"excerpt":{"rendered":"<p>Face \u00e0 des troubles digestifs chroniques sans anomalie d\u00e9cel\u00e9e, comment la compr\u00e9hension des pr\u00e9dispositions g\u00e9n\u00e9tiques et de l&rsquo;interaction entre g\u00e8nes et environnement peut-elle enrichir l&rsquo;accompagnement du patient ?<\/p>","protected":false},"author":1,"featured_media":287,"parent":21,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-288","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/pages\/288","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/comments?post=288"}],"version-history":[{"count":1,"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/pages\/288\/revisions"}],"predecessor-version":[{"id":320,"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/pages\/288\/revisions\/320"}],"up":[{"embeddable":true,"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/pages\/21"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/media\/287"}],"wp:attachment":[{"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/media?parent=288"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}