{"id":307,"date":"2026-11-10T10:11:44","date_gmt":"2026-11-10T09:11:44","guid":{"rendered":"https:\/\/adnacademy.yohanndeprez.fr\/?page_id=307"},"modified":"2026-11-10T17:01:55","modified_gmt":"2026-11-10T16:01:55","slug":"agenesie-dentaire","status":"publish","type":"page","link":"https:\/\/adn-academy.com\/en\/cas-cliniques\/agenesie-dentaire\/","title":{"rendered":"Ag\u00e9n\u00e9sie dentaire"},"content":{"rendered":"<div class=\"wp-block-group adn-hero is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-hero-inner is-layout-flow wp-block-group-is-layout-flow\">\n<nav class=\"breadcrumb\" aria-label=\"Breadcrumb\"><a href=\"\/en\/\">Home<\/a><span aria-hidden=\"true\">\/<\/span><a href=\"\/en\/ressources\/\">Resources<\/a><span aria-hidden=\"true\">\/<\/span><a href=\"\/en\/cas-cliniques\/\">Clinical cases<\/a><span aria-hidden=\"true\">\/<\/span><span aria-current=\"page\">Ag\u00e9n\u00e9sie dentaire<\/span><\/nav>\n\n\n<p class=\"adn-hero-eyebrow wp-block-paragraph\">Clinical case \u00b7 Dentistry<\/p>\n\n\n<h1 class=\"wp-block-heading\">Ag\u00e9n\u00e9sie dentaire<\/h1>\n\n\n<p class=\"adn-hero-description wp-block-paragraph\">Pourquoi certaines dents ne se d\u00e9veloppent-elles jamais, malgr\u00e9 une croissance normale et l&#x27;absence de traumatisme ? Les pr\u00e9dispositions g\u00e9n\u00e9tiques peuvent-elles expliquer certaines anomalies du d\u00e9veloppement dentaire ?<\/p>\n\n\n<p class=\"adn-clinical-author wp-block-paragraph\">Auteure : <a href=\"\/en\/a-propos\/\">Dr Clotilde Neyra<\/a><\/p>\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"#etude\">Read the case<\/a><\/div>\n\n\n<\/div>\n\n<\/div>\n\n<\/div>\n\n\n<section id=\"etude\" class=\"wp-block-group adn-home-section adn-course-section adn-clinical-detail is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-home-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-clinical-layout is-layout-flow wp-block-group-is-layout-flow\"><div class=\"wp-block-group adn-clinical-story is-layout-flow wp-block-group-is-layout-flow\"><figure class=\"wp-block-image size-full adn-clinical-image\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/adn-academy.com\/wp-content\/uploads\/2026\/11\/agenesie-dentaire-visuel-equipe.png\" alt=\"Illustration : Ag\u00e9n\u00e9sie dentaire\" class=\"wp-image-345\" width=\"1434\" height=\"825\" srcset=\"https:\/\/adn-academy.com\/wp-content\/uploads\/2026\/11\/agenesie-dentaire-visuel-equipe.png 1434w, https:\/\/adn-academy.com\/wp-content\/uploads\/2026\/11\/agenesie-dentaire-visuel-equipe-300x173.png 300w, https:\/\/adn-academy.com\/wp-content\/uploads\/2026\/11\/agenesie-dentaire-visuel-equipe-1024x589.png 1024w, https:\/\/adn-academy.com\/wp-content\/uploads\/2026\/11\/agenesie-dentaire-visuel-equipe-768x442.png 768w, https:\/\/adn-academy.com\/wp-content\/uploads\/2026\/11\/agenesie-dentaire-visuel-equipe-18x10.png 18w\" sizes=\"auto, (max-width: 1434px) 100vw, 1434px\" \/><\/figure>\n<h2 id=\"contexte\" class=\"wp-block-heading\">Contexte clinique<\/h2>\n<p class=\"wp-block-paragraph\">Thomas, 14 ans, consulte accompagn\u00e9 de ses parents pour l&#x27;absence de plusieurs dents permanentes. L\u2019examen initial montre une bonne hygi\u00e8ne bucco-dentaire. Un suivi r\u00e9gulier a \u00e9t\u00e9 fait pendant l\u2019enfance. Il est constat\u00e9 l\u2019absence des deux incisives lat\u00e9rales sup\u00e9rieures et d\u2019une pr\u00e9molaire. Une radiographie panoramique confirme l\u2019absence de germes.<\/p>\n<p class=\"wp-block-paragraph\">Cette situation pr\u00e9occupe l&#x27;adolescent. Il est g\u00ean\u00e9 par l&#x27;esth\u00e9tique de son sourire et par la perspective de futurs traitements orthodontiques. Sa m\u00e8re mentionne que plusieurs membres de la famille pr\u00e9sentent \u00e9galement des dents manquantes.<\/p>\n<h2 id=\"analyse\" class=\"wp-block-heading\">Le g\u00e8ne en cause : MSX1<\/h2>\n<p class=\"wp-block-paragraph\">L&#x27;analyse de l&#x27;histoire familiale oriente vers une origine g\u00e9n\u00e9tique. Une exploration met en \u00e9vidence un variant du g\u00e8ne MSX1, impliqu\u00e9 dans le d\u00e9veloppement embryonnaire des dents. Ce g\u00e8ne joue un r\u00f4le essentiel dans les premi\u00e8res \u00e9tapes de la formation dentaire. Certaines variations peuvent \u00eatre associ\u00e9es \u00e0 des ag\u00e9n\u00e9sies dentaires isol\u00e9es ou familiales.<\/p>\n<p class=\"wp-block-paragraph\">Cette d\u00e9couverte permet d&#x27;expliquer pourquoi plusieurs membres de la famille pr\u00e9sentent des anomalies similaires. Et d\u2019anticiper la prise en charge des autres membres de la famille, sans qu&#x27;une mauvaise hygi\u00e8ne ou un facteur environnemental en soit responsable.<\/p>\n<h2 id=\"genetique\" class=\"wp-block-heading\">L\u2019int\u00e9r\u00eat de la g\u00e9n\u00e9tique et de l\u2019\u00e9pig\u00e9n\u00e9tique<\/h2>\n<p class=\"wp-block-paragraph\">La g\u00e9n\u00e9tique permet ici de mieux comprendre l&#x27;origine de l&#x27;ag\u00e9n\u00e9sie dentaire et d&#x27;\u00e9valuer le risque de survenue de cette anomalie chez les apparent\u00e9s.<\/p>\n<p class=\"wp-block-paragraph\">La s\u00e9v\u00e9rit\u00e9 des manifestations cliniques peut varier d\u2019un individu \u00e0 l\u2019autre, m\u00eame au sein d\u2019une m\u00eame famille, en raison d\u2019une expressivit\u00e9 variable. Cette variabilit\u00e9 peut notamment \u00eatre influenc\u00e9e par d\u2019autres facteurs g\u00e9n\u00e9tiques, \u00e9pig\u00e9n\u00e9tiques et environnementaux.<\/p>\n<h2 id=\"accompagnement\" class=\"wp-block-heading\">Une prise en charge personnalis\u00e9e<\/h2>\n<p class=\"wp-block-paragraph\">La prise en charge repose sur une collaboration entre chirurgien-dentiste, orthodontiste et g\u00e9n\u00e9ticien. L&#x27;objectif est de pr\u00e9server la fonction masticatoire, l&#x27;\u00e9quilibre occlusal et l&#x27;esth\u00e9tique du sourire. En fonction de la croissance et de la situation clinique, diff\u00e9rentes options peuvent \u00eatre envisag\u00e9es : fermeture orthodontique des espaces, maintien des dents temporaires ou remplacement proth\u00e9tique \u00e0 l&#x27;\u00e2ge adulte.<\/p>\n<p class=\"wp-block-paragraph\">La compr\u00e9hension de l&#x27;origine g\u00e9n\u00e9tique aide Thomas et sa famille \u00e0 mieux appr\u00e9hender le traitement et son \u00e9volution \u00e0 long terme.<\/p>\n<\/div>\n<aside class=\"wp-block-group adn-course-panel adn-clinical-aside is-layout-flow wp-block-group-is-layout-flow\"><p class=\"wp-block-paragraph\">In this clinical case<\/p>\n<nav class=\"adn-clinical-nav\" aria-label=\"In this clinical case\"><a href=\"#contexte\">Contexte clinique <span aria-hidden=\"true\">\u2192<\/span><\/a><a href=\"#analyse\">Le g\u00e8ne en cause : MSX1 <span aria-hidden=\"true\">\u2192<\/span><\/a><a href=\"#genetique\">L\u2019int\u00e9r\u00eat de la g\u00e9n\u00e9tique et de l\u2019\u00e9pig\u00e9n\u00e9tique <span aria-hidden=\"true\">\u2192<\/span><\/a><a href=\"#accompagnement\">Une prise en charge personnalis\u00e9e <span aria-hidden=\"true\">\u2192<\/span><\/a><\/nav><p class=\"wp-block-paragraph\">D\u00e9couvrez notre formation G\u00e9n\u00e9tique &amp; Dentisterie pour approfondir ces sujets.<\/p>\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\"><div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"\/en\/formations\/genetique-dentisterie\/\">Explore the course<\/a><\/div><\/div><\/aside>\n<\/div>\n\n<\/div>\n\n<\/section>\n\n\n\n<section id=\"programme\" class=\"wp-block-group adn-home-section adn-course-section is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-home-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-course-enquiry is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-course-copy is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-section-heading is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"adn-section-label wp-block-paragraph\">Explore further<\/p>\n\n\n<h2 class=\"wp-block-heading\"><mark style=\"background-color:rgba(0, 0, 0, 0);color:#2E4057\" class=\"has-inline-color\">Get<\/mark> <mark style=\"background-color:rgba(0, 0, 0, 0);color:#279D5E\" class=\"has-inline-color\">the detailed programme<\/mark><\/h2>\n\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">Explore these topics further with the <strong>Genetics &amp; Dentistry<\/strong>course. Discover its content and speak to the ADNAcademy team.<\/p>\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-outline is-style-outline--1\"><a class=\"wp-block-button__link wp-element-button\" href=\"\/en\/formations\/genetique-dentisterie\/\">Explore the course<\/a><\/div>\n\n<\/div>\n\n<\/div>\n\n\n<div class=\"wp-block-group adn-course-form is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"adn-form-consent\"><p>This form is provided by HubSpot. Allow it to load to receive the programme or request enrolment.<\/p><button type=\"button\" class=\"adn-button\" data-cookie-settings>Show the form<\/button><\/div><div class=\"adn-hubspot-mount\" data-hubspot-form=\"bf217b99-e65a-4002-8719-c1bf9428132f\"><\/div><noscript><p>Enable JavaScript to view the form, or contact us at <a href=\"mailto:contact@adn-academy.com\">contact@adn-academy.com<\/a>.<\/p><\/noscript>\n\n<\/div>\n\n<\/div>\n\n<\/div>\n\n<\/section>\n\n\n<section class=\"wp-block-group adn-home-section adn-course-section adn-section-tinted adn-clinical-back is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group adn-home-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"\/en\/cas-cliniques\/\">All clinical cases<\/a><\/div>\n\n\n<div class=\"wp-block-button is-style-outline is-style-outline--2\"><a class=\"wp-block-button__link wp-element-button\" href=\"\/en\/ressources\/\">Explore our resources<\/a><\/div>\n\n<\/div>\n\n<\/div>\n\n<\/section>","protected":false},"excerpt":{"rendered":"<p>Accueil\/Ressources\/Cas cliniques\/Ag\u00e9n\u00e9sie dentaire Cas clinique \u00b7 Dentisterie Ag\u00e9n\u00e9sie dentaire Pourquoi certaines dents ne se d\u00e9veloppent-elles jamais, malgr\u00e9 une croissance normale et l&#x27;absence de traumatisme ? Les pr\u00e9dispositions g\u00e9n\u00e9tiques peuvent-elles expliquer certaines anomalies du d\u00e9veloppement dentaire ? Auteure : Dr Clotilde Neyra Contexte clinique Thomas, 14 ans, consulte accompagn\u00e9 de ses parents pour l&#x27;absence de plusieurs [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":345,"parent":21,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-307","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/pages\/307","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/comments?post=307"}],"version-history":[{"count":3,"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/pages\/307\/revisions"}],"predecessor-version":[{"id":348,"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/pages\/307\/revisions\/348"}],"up":[{"embeddable":true,"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/pages\/21"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/media\/345"}],"wp:attachment":[{"href":"https:\/\/adn-academy.com\/en\/wp-json\/wp\/v2\/media?parent=307"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}